Renal Response to Acid Load after Phenformin

Renal response to acid load after phenformin.

Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.

Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes.

Idiopathic uric acid nephrolithiasis is characterized by elevated urinary net acid excretion and insufficient buffering by ammonium, resulting in excessively acidic urine and titration of the relatively soluble urate anion to insoluble uric acid. Patients with type 2 diabetes have similar changes in urinary pH, net acid excretion, and ammonium in 24-h urine collections at baseline, even after c...

Renal response to amino acid infusion in essential hypertension.

In the present study, we evaluated the renal response to a 4-hour infusion of amino acids in essential hypertensive patients, as well as the effects that dietary sodium restriction and enalapril (a converting enzyme inhibitor) had on this renal response. During normal sodium intake, amino acid infusion significantly increased renal plasma flow from 383 +/- 58 to 478 +/- 51 mL/min and glomerular...

Dietary potential renal Acid load in venezuelan children.

OBJECTIVE Our aim was to determine and analyze the dietary PRAL and food composition pattern in apparently healthy children from 1 to 6 years of age. METHODS Parents of 52 children were selected by convenience, in an outpatient clinic of healthy children. Dietary quality and pattern was assessed by 24 hour recall and food frequency questionnaire. We focused on the intake of macronutrients and...

Paleolithic diet, sweet potato eaters, and potential renal acid load.